Documentation

Last Updated: October 7, 2025

Introduction

This is the TFactorTx documentation. Here you’ll find information about the data sources and how the database and detailed TF cards are derived from them.

Data and Other Sources

The data for the database and detailed TF cards was compiled from publicly available and openly licensed sources. The sources are listed in the table below, including links to the original sources and appropriate recent citations.

Data SourceCategoryLinkCitation
TFClassClassificationhttp://tfclass.bioinf.med.uni-goettingen.de/https://pubmed.ncbi.nlm.nih.gov/29087517/
EnsemblExternal Database IDshttps://useast.ensembl.org/https://pubmed.ncbi.nlm.nih.gov/39656687/
HGNCExternal Database IDshttps://www.genenames.org/https://pubmed.ncbi.nlm.nih.gov/36243972/
NCBIExternal Database IDshttps://www.ncbi.nlm.nih.gov/https://pubmed.ncbi.nlm.nih.gov/39526373/
UniProtExternal Database IDshttps://www.uniprot.org/https://pubmed.ncbi.nlm.nih.gov/39552041/
JASPARExternal Database IDshttps://jaspar.elixir.no/https://pubmed.ncbi.nlm.nih.gov/37962376/
Open TargetsTarget-Disease Modulehttps://www.opentargets.org/https://pubmed.ncbi.nlm.nih.gov/39657122/
PMID 35343830Target-Aging Modulehttps://pubmed.ncbi.nlm.nih.gov/35343830/https://pubmed.ncbi.nlm.nih.gov/35343830/
HAGRTarget-Aging Modulehttps://genomics.senescence.info/https://pubmed.ncbi.nlm.nih.gov/37933854/
Open GenesTarget-Aging Modulehttps://open-genes.com/https://pubmed.ncbi.nlm.nih.gov/37665017/
AgingReGTarget-Aging Modulehttps://bio.liclab.net/Aging-ReG/https://pubmed.ncbi.nlm.nih.gov/37805704/
SeneQuestTarget-Aging Modulehttps://senequest.net/https://senequest.net/about
PharosTarget-Development Modulehttps://pharos.nih.gov/https://pubmed.ncbi.nlm.nih.gov/36624666/
DGIdbTarget-Development Modulehttps://dgidb.org/https://pubmed.ncbi.nlm.nih.gov/37953380/
TTDTarget-Development Modulehttps://idrblab.net/ttd/https://pubmed.ncbi.nlm.nih.gov/37713619/
ChEMBLTarget-Development Modulehttps://www.ebi.ac.uk/chembl/https://pubmed.ncbi.nlm.nih.gov/37933841/

Additional sources may be added over time as new datasets become available. All sources are subject to the licensing terms specified by their respective creators.

Other sources include: "Collections of Icons and Workflows for Robotic and Generative AI Agent-oriented Research for Health and Sustainability Sciences, Alex Zhavoronkov et al, Insilico Medicine, 2024, CC BY-NC-SA."

Methodology

This section summarizes how database and TF card elements are derived from the listed data sources. It provides a high-level description of the processing and mapping steps used to generate ranks and labels shown throughout TFactorTx.

Database
ElementData SourceDescription
Gene NameHGNCTranscription factor gene name. Click entry to view detailed information in the TF card.
Overall RankAll "Target-Disease Module" and "Target-Aging Module" data sourcesOverall rank based on disease associations and aging data. Lower is better.
All Diseases RankOpen TargetsRank based on the sum of Open Targets disease association scores across all diseases linked to this transcription factor.
ARDs RankOpen TargetsRank based on the sum of Open Targets disease association scores across selected age-related diseases (ARDs) linked to this transcription factor.
Strongest Linked ARDOpen TargetsAge-related disease with highest Open Targets assocation score for this transcription factor.
Aging RankAll "Target-Aging Module" data sourcesRank based on number of aging database entries across all species.
Human Link Y/NAll "Target-Aging Module" data sourcesIndicates if any evidence linking this transcription factor to human aging is available across checked databases.
M. musculus LinkPMID 35343830, HAGR, Open GenesOverall conclusion about the influence of this transcription factor on mouse aging, based on evidence across checked databases.
C. elegans LinkPMID 35343830, HAGR, Open GenesOverall conclusion about the influence of this transcription factor on worm aging, based on evidence across checked databases.
D. melanogaster LinkPMID 35343830, HAGR, Open GenesOverall conclusion about the influence of this transcription factor on fly aging, based on evidence across checked databases.
Development LevelAll "Target-Development Module" data sourcesOverall development level of targeting this transcription factor with drugs, based on evidence across checked databases.
Pharos TDLPharosTarget development level (TDL) according to Pharos database.
TF Cards
ElementData SourceDescription
TFactorTx IDsHGNCInternal TFactorTx ID and gene name for this transcription factor.
ClassificationTFClassClassification of this transcription factor based on the TFClass hierarchy: Superclass → Class → Family.
External Database IDsAll "External Database IDs" data sources and Open TargetsIdentifiers and links to entries for this transcription factor in major databases. JASPAR via UniProt ID and Open Targets via Ensembl ID.
Target-Disease ModuleOpen TargetsCounts, aggregated association scores, and ranks in parentheses for total, low, medium, and high confidence target–disease associations for this transcription factor according to Open Targets, plus for selected age-related diseases (ARDs).
Target-Aging ModuleAll "Target-Aging Module" data sourcesOverview of evidence linking this transcription factor to aging in humans and different model organisms, according to the indicated databases.
Target-Development ModuleAll "Target-Development Module" data sourcesOverview of drugs and drug development efforts for this transcription factor, according to the indicated databases.

License and Attribution

This project is dedicated to the public domain under the terms of the Creative Commons Zero v1.0 Universal Public Domain Dedication (CC0 1.0).

All content has been compiled exclusively from publicly available and openly licensed sources, which are cited in the above project documentation. No proprietary or confidential materials have been used.

TFactorTx was created and is maintained by Dr. Fabian Fischer ORCID LinkedIn