Discover the Power of Transcription Factors (TFs)
Did you know that humans have over 1,600 transcription factors, with hundreds linked
to aging and disease, yet only 23 of them are targeted by approved drugs?
TFs as Drug Targets
Nuclear receptors, a specific TF class, are highly succesful as drug targets. Unlike most other TFs, nuclear receptors can be targeted directly with small molecules.
Unexplored TF Target Space
While most TFs are traditionally considered 'undruggable,' this paradigm is rapidly changing with the advancement of new modalities and improved small molecules.
This unlocks new opportunities for targeting TFs linked to aging and disease.
TFactorTx Database
The TFactorTx database provides an entry point to identify research and therapeutic targets from the space of all 1,600+ human TFs.
Aging, Disease, and Drug Associations
Information from several other databases (see documentation) is aggregated to provide a convenient overview of TFs links to aging across several species, relevance for human disease, and current drug development states.
Searching, Filtering, and Exploring
Use the intuitive searching and filtering options to narrow in on targets of interest. Check detailed TF cards to better understand your targets and explore linked databases to dive deeper.