An Open Source Database for
Human Transcription Factors
Accelerate your research with our manually curated database of human transcription factors and their links to aging, disease, and drug development.
Explore this database to find your next research or therapeutic target.
It will be updated periodically and more data/features will be added over time.
Discover the Power of Transcription Factors (TFs)
Did you know that humans have over 1,600 transcription factors, with hundreds linked to aging and disease, yet only 23 of them are targeted by approved drugs?
TFs as Drug Targets
Nuclear receptors, a specific TF class, are highly succesful as drug targets, despite being the smallest target class. Unlike most other TFs, nuclear receptors can be targeted directly with small molecules.
Unexplored TF Target Space
While most other TFs have been considered 'undruggable', this paradigm is rapidly changing with the advancement of new modalities and improved small molecules.
This unlocks new opportunities for therapeutically targeting TFs linked to disease and aging.
TFactorTx Database
The TFactorTx database provides an entry point to identify research and therapeutic targets from the space of all 1,600+ human TFs.
Aging, Disease, and Drug Associations
Information from several other databases (see documentation) is aggregated to provide a convenient overview of TFs links to aging across several species, relevance for human disease, and current drug development status.
Searching, Filtering, and Exploring
Use the intuitive searching and filtering options to narrow in on targets of interest. Check detailed TF cards to better understand your targets and explore linked databases to dive deeper.
